1-(3-acetylthio-2-trifluoromethylpropanoyl)-4,4-difluoro-L-proline → 1-(3-mercapto-2-trifluoromethylpropanoyl)-4,4-difluoro-L-proline

HRID 262713노트

반응식

HRID 262713 반응식
C([S:4][CH2:5][CH:6]([C:19]([F:22])([F:21])[F:20])[C:7]([N:9]1[CH2:16][C:15]([F:18])([F:17])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.C(SCC(C(F)(F)F)C(N1CCC[C@H]1C(O)=O)=O)(=O)C>>[SH:4][CH2:5][CH:6]([C:19]([F:22])([F:20])[F:21])[C:7]([N:9]1[CH2:16][C:15]([F:17])([F:18])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

참가 물질

3

반응물 2

HCID 228079941-(3-acetylthio-2-trifluoromethylpropanoyl)-4,4-difluoro-L-prolineHCID 541522191-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline

생성물 1

HCID 228079951-(3-mercapto-2-trifluoromethylpropanoyl)-4,4-difluoro-L-proline

실험 절차

By substituting 1-(3-acetylthio-2-trifluoromethylpropanoyl)-4,4-difluoro-L-proline for the 1-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline in the procedure of Example 4, 1-(3-mercapto-2-trifluoromethylpropanoyl)-4,4-difluoro-L-proline is obtained.

출처 및 근거

ORD 기록
ord-975ec97571124ec28c3fd9d70ce42024
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154935

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