Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → Brl 16657
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 반응물 | 4-Trifluoromethylphenylchroman-7-ol | HCID 86735563 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Brl 16657 | HCID 42989 | — |
반응 단계
Dimethylaminoethylchloride hydrochloride (1.5 g) was added to 2,2-dimethyl-4-(4-trifluoromethylphenylchroman-7-ol (1.0 g), potassium carbonate (4.0 g) and potassium iodide (1.5 g) in acetone (50 ml) and the mixture refluxed for 2 days. The mixture was filtered and the acetone was evaporated under reduced pressure. The resulting crude oil was chromatographed on alumina. Elution with ether:petrol (1:1) gave a clear oil which after dissolution in dry ether and passage of dry halogen chloride through the solution yielded the required chroman as the hydrochloride salt (0.35 g), m.p. 200°-203° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04148909 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-3373465bb8a242568b7f601f92f97f86 |
| 출처 메모 | uspto-grants-1979_04 |