Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → (4S)-Oct-1-yn-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1-Octyn-4-ol | HCID 103656 | — |
| 반응물 | 4-Benzoyloxy-1-octyne | HCID 20442054 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | (4S)-Oct-1-yn-4-ol | HCID 12786164 | — |
반응 단계
A solution of 1.15 g (5.0 mmoles) of (S)-4-benzoyl-oxy-1-octyne (Example 141) and 1.40 g (25 mmoles) of potassium hydroxide in 50 ml of 10:1 methanol-water is allowed to stand at room temperature for 24 hours. The bulk of the methanol is evaporated at room temperature, and the mixture is extracted with ether. The extract is washed with brine, dried over magnesium sulfate, and evaporated to give a colorless oil, identical to 4-hydroxy-1-octyne [α]D25 = +17+ 1.0° (C=0.77, ethyl acetate). This compound has the (S)-configuration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04154954 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-047c85d251bc4435a0923f61a79e2469 |
| 출처 메모 | uspto-grants-1979_05 |