참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | N-(3-Fluoro-4-isopropyl-phenyl)-N'-methyl-urea | HCID 21317057 | — |
| 반응물 | HCID 178486302 | HCID 178486302 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 생성물 | 3-(3-Fluoro-4-isopropyl-phenyl)-5-methyltetrahydro-1,3,5-oxadiazin-4-one | HCID 21317058 | 82% |
반응 단계
N-(3-Fluoro-4-isopropyl-phenyl)-N'-methyl-urea (one mol=210 g.) and polyoxymethylene (1 mol=90 g.) are dissolved in toluene (800 cc.) in the presence of para-toluenesulphonic acid (0.3 mol=51.6 g.) as a catalyst and of dimethylformamide (0.3 mol=22 g.), and the mixture is heated for 15 minutes at 80° C. After having washed the solution with water and then concentrated it, 3-(3-fluoro-4-isopropyl-phenyl)-5-methyltetrahydro-1,3,5-oxadiazin-4-one is obtained in the form of an oil which is purified by dissolving in hot hexane and recrystallising.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04155747 |
|---|
| 출처 데이터셋 | uspto-grants-1979_05 |
|---|
| ORD ID | ord-510a4bf1a90642f583f7a61a6c0b2b29 |
|---|
| 출처 메모 | uspto-grants-1979_05 |
|---|
