Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Methyl-3(carboethoxypropyl)-7-(pivaloyloxymethyl)xanthine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Ethyl 4-iodobutanoate | HCID 10890062 | — |
| 반응물 | 1-Methyl-7-(pivaloyloxymethyl)xanthine | HCID 12879841 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Chloroform ethanol | HCID 21889567 | — |
| 생성물 | 1-Methyl-3(carboethoxypropyl)-7-(pivaloyloxymethyl)xanthine | HCID 12879842 | 123.6% |
반응 단계
A mixture of 1-methyl-7-(pivaloyloxymethyl)xanthine (350 mg, 1.25 mmes) sodium carbonate (265 mg, 2.50 mmoles) and ethyl 4-iodobutyrate (384 μl, 2.50 mmole) in 5.8 ml dry DMF was stirred under nitrogen at room temperature for 18 hours. Water was added and the reaction mixture extracted with chloroform. After drying, the extracts were stripped to leave a yellow oil which goes to chromotographed on four thick silica gel plates with 10% EtOH/CHCl3. The band was scraped off and eluted with 100 ml of 25% EtOH/CHCl3 to yield 609 mg of the desired product as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04156081 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-6d48475f834d47b1a6bcd738463e1005 |
| 출처 메모 | uspto-grants-1979_05 |