참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Cyanopyridine | HCID 7506 | — |
| 반응물 | Pyrazine-2-Carboxylic Acid Hydrazide | HCID 258796 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 178419986 | HCID 178419986 | — |
반응 단계
Sodium (0.4 grams) is added to pyridine-4-carbonitrile (8.3 grams, 0.08 mole) in methanol, and the solution is allowed to stand 30 minutes at room temperature. A suspension of pyrazine carboxylic acid hydrazide (9.6 grams, 0.07 mole) in methanol (160 ml.) is added, and the resulting solution is heated at reflux for 30 minutes. After cooling, the intermediate acylamidrazone is collected by filtration. The acyclic intermediate is then heated at 260° C. for 15 minutes, after which the reaction is cooled to room temperature. Upon recrystallization from acetonitrile-water, 3-pyrazinyl-5-(4-pyridyl)-1,2,4-triazole is obtained, m.p. 251°-252.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04156085 |
|---|
| 출처 데이터셋 | uspto-grants-1979_05 |
|---|
| ORD ID | ord-2dd9c049b902440eb6c979fbf9c98166 |
|---|
| 출처 메모 | uspto-grants-1979_05 |
|---|
