참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Ethyl 2-bromovalerate | HCID 79071 | — |
| 반응물 | Phthalimide potassium salt | HCID 24194345 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl alpha-phthalimidopentanoate | HCID 13791337 | — |
반응 단계
To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04148998 |
|---|
| 출처 데이터셋 | uspto-grants-1979_04 |
|---|
| ORD ID | ord-238e2c7868bf4c0ab667f4ccfcc35579 |
|---|
| 출처 메모 | uspto-grants-1979_04 |
|---|
