Water → Ethyl alpha-phthalimidopentanoate

HRID 26313

반응식

HRID 26313 반응식
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH2:13]([O:15][C:16](=[O:22])[CH:17](Br)[CH2:18][CH2:19][CH3:20])[CH3:14].C(Cl)(Cl)Cl.O>CN(C)C=O>[C:1]1(=[O:11])[N:5]([CH:17]([CH2:18][CH2:19][CH3:20])[C:16]([O:15][CH2:13][CH3:14])=[O:22])[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

참가 물질

6

반응물 4

HCID 962WaterHCID 6212ChloroformHCID 79071Ethyl 2-bromovalerateHCID 24194345Phthalimide potassium salt

생성물 1

HCID 13791337Ethyl alpha-phthalimidopentanoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

반응 조건

온도
60 °C

실험 절차

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

후처리

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with chloroform
  3. extractionextracted with 0.1 N sodium hydroxide and with water
  4. dry with materialAfter drying over sodium sulfate
  5. customthe chloroform is removed

출처 및 근거

ORD 기록
ord-238e2c7868bf4c0ab667f4ccfcc35579
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148998

연결된 노트

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