DL-norvaline → 2-(1H-Pyrrol-1-YL)pentanoic acid
반응식
[NH2:1][CH:2]([CH2:6][CH2:7][CH3:8])[C:3]([OH:5])=[O:4].C([O-])(=O)C.[Na+].CO[CH:16]1[CH2:20][CH2:19][CH:18](OC)O1>C(O)(=O)C>[N:1]1([CH:2]([CH2:6][CH2:7][CH3:8])[C:3]([OH:5])=[O:4])[CH:16]=[CH:20][CH:19]=[CH:18]1참가 물질
5
실험 절차
2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.
후처리
- temperatureThis solution is heated
- temperatureis then refluxed for 5 minutes
- temperatureThe mixture is refluxed for a further 2 minutes
- customevaporated
- washwashed with water
- customdried
- customthe solvent removed under vacuo
출처 및 근거
- ORD 기록
- ord-dc120655c6e54af49941a144e86ef0e0
- 출처 데이터셋
- uspto-grants-1979_04
- 특허 번호
- US04148998
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