DL-norvaline → 2-(1H-Pyrrol-1-YL)pentanoic acid

HRID 26314

반응식

HRID 26314 반응식
[NH2:1][CH:2]([CH2:6][CH2:7][CH3:8])[C:3]([OH:5])=[O:4].C([O-])(=O)C.[Na+].CO[CH:16]1[CH2:20][CH2:19][CH:18](OC)O1>C(O)(=O)C>[N:1]1([CH:2]([CH2:6][CH2:7][CH3:8])[C:3]([OH:5])=[O:4])[CH:16]=[CH:20][CH:19]=[CH:18]1

참가 물질

5

반응물 3

HCID 824DL-norvalineHCID 790982,5-DimethoxytetrahydrofuranHCID 517045Sodium Acetate

생성물 1

HCID 114125932-(1H-Pyrrol-1-YL)pentanoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.

후처리

  1. temperatureThis solution is heated
  2. temperatureis then refluxed for 5 minutes
  3. temperatureThe mixture is refluxed for a further 2 minutes
  4. customevaporated
  5. washwashed with water
  6. customdried
  7. customthe solvent removed under vacuo

출처 및 근거

ORD 기록
ord-dc120655c6e54af49941a144e86ef0e0
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148998

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