Dimethylformamide → 2-Sulfo-2-(1-pyrryl)acetyl chloride
반응식
[S:1]([CH:5]([N:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1)[C:6](O)=[O:7])([OH:4])(=[O:3])=[O:2].S(Cl)([Cl:16])=O.CN(C)C=O.CCCCCC>CCOCC>[S:1]([CH:5]([N:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1)[C:6]([Cl:16])=[O:7])([OH:4])(=[O:3])=[O:2]참가 물질
6
반응 조건
- 온도
- 40 °C
실험 절차
2-Sulfo-2-(1-pyrryl)acetic acid is treated with thionyl chloride in ether at room temperature according to the general procedure in J. Med. Chem., 15, 1105 (1972) until the evolution of gas stops. Dimethylformamide is added, the solution is warmed to about 40° C. for 1 hour. Then ether is added, followed by hexane and the solution cooled to about -25° C. 2-Sulfo-2-(1-pyrryl)acetyl chloride is isolated from the solvent by decantation.
후처리
- temperaturethe solution cooled to about -25° C
출처 및 근거
- ORD 기록
- ord-e1561fb8a76442beaa3c4d1d9f935f62
- 출처 데이터셋
- uspto-grants-1979_04
- 특허 번호
- US04148998
반응 노트
불러오는 중…