3-((Acetyloxy)methyl)-7-amino-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid → HCID 86736468, 화합물

HRID 26320

반응식

HRID 26320 반응식
[S:1]([CH:5]([N:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1)[C:6](Cl)=[O:7])([OH:4])(=[O:3])=[O:2].[C:14]([O:17][CH2:18][C:19]1[CH2:26][S:25][CH:24]2[N:21]([C:22](=[O:28])[CH:23]2[NH2:27])[C:20]=1[C:29]([OH:31])=[O:30])(=[O:16])[CH3:15].C(=O)(O)[O-].[Na+]>CCOCC.O>[C:14]([O:17][CH2:18][C:19]1[CH2:26][S:25][CH:24]2[N:21]([C:22](=[O:28])[CH:23]2[NH:27][C:6](=[O:7])[CH:5]([S:1]([OH:4])(=[O:3])=[O:2])[N:9]2[CH:13]=[CH:12][CH:11]=[CH:10]2)[C:20]=1[C:29]([OH:31])=[O:30])(=[O:16])[CH3:15]

참가 물질

6

반응물 3

HCID 137293-((Acetyloxy)methyl)-7-amino-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acidHCID 516892Sodium BicarbonateHCID 867364672-Sulfo-2-(1-pyrryl)acetyl chloride

생성물 1

HCID 86736468HCID 86736468, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 2-sulfo-2-(1-pyrryl)acetyl chloride (1 equivalent) in ether is added to 3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid (1 equivalent) and sodium bicarbonate (about 3 equivalents) in water at about 0° C. After about 30 minutes the phases are separated, the pH adjusted to about 6.5 and the aqueous phase extracted with ethyl acetate. The ethyl acetate is dried over megnesium sulfate, filtered and evaporated to give the title compound.

후처리

  1. customAfter about 30 minutes the phases are separated
  2. extractionthe aqueous phase extracted with ethyl acetate
  3. dry with materialThe ethyl acetate is dried over megnesium sulfate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-dad01d312966486fa7e7e8963f0579b3
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148998

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