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Triethylamine → HCID 70605765, 화합물

HRID 26324
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HRID 26324 반응식
[N:1]1([CH:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:7]([O-:9])=O)[CH:5]=[CH:4][CH:3]=[CH:2]1.C(N(CC)CC)C.ClC(OCC(C)C)=O.[NH2:30][C:31]1([O:44][CH3:45])[C:38](=[O:39])[N:37]2[CH:32]1[S:33][CH2:34][C:35]([CH3:43])=[C:36]2[C:40]([OH:42])=[O:41]>O1CCCC1>[C:10]([CH:6]([N:1]1[CH:2]=[CH:3][CH:4]=[CH:5]1)[C:7]([NH:30][C:31]1([O:44][CH3:45])[C:38](=[O:39])[N:37]2[CH:32]1[S:33][CH2:34][C:35]([CH3:43])=[C:36]2[C:40]([OH:42])=[O:41])=[O:9])([O:12][CH2:13][CH3:14])=[O:11]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

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HCID 8471Triethylamine2회HCID 62365Isobutyl chloroformateHCID 204670347-Amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidHCID 85953691HCID 85953691, 화합물

생성물 1

HCID 70605765HCID 70605765, 화합물

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매
2회

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온도
0 °C

실험 절차

2-(1-Pyrryl)propanedioic acid, 3-ethyl ester, 1 equivalent and 1 equivalent of triethylamine is added to tetrahydrofuran (THF) which is cooled to 0° C. While stirring, iso-butyl chloroformate, 1 equivalent, is added and the temperature is maintained at 0° C. for about 15 minutes. A cold solution of 7-amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1 equivalent, and triethylamine, 1 equivalent, in 50% aqueous THF is added with stirring to the previous solution.

후처리

  1. temperaturethe temperature is maintained at 0° C. for about 15 minutes
  2. stirringwith stirring to the previous solution

출처 및 근거

ORD 기록
ord-3c69794f1ed54ebdb06c74503966f881
출처 데이터셋
uspto-grants-1979_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04148998

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