tert-Butyl isocyanate → HCID 21316843, 화합물

HRID 263267

반응식

HRID 263267 반응식
[CH3:1][C:2]([NH2:6])([CH3:5])[C:3]#[N:4].[C:7]([N:11]=[C:12]=[O:13])([CH3:10])([CH3:9])[CH3:8]>>[C:3]([C:2]([NH:6][C:12]([NH:11][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:13])([CH3:5])[CH3:1])#[N:4]

참가 물질

3

반응물 2

HCID 62412tert-Butyl isocyanateHCID 880222-Amino-2-methylpropionitrile

생성물 1

HCID 21316843HCID 21316843, 화합물

실험 절차

In a nitrogen atmosphere, 24.8 g. (0.3 mole) 2-methyl-2-aminopropionitrile and 30.7 g. (0.3 mole) t-butyl isocyanate, 97%, are combined and stirred for 5 minutes. At the end of this period, the mixture is filtered and 1 ml. of pyridine is added to the filtrate. This mixture is heated in an oil bath for one and one-half hours, keeping the temperature of the bath below 70°. The solid is recrystallized from methanol:water, 60:40, to give N-(1-cyano-1-methylethyl)-N'-(1,1-dimethylethyl)urea, m.p. 204°-5°; Anal. Calcd. for C9H17N3O; C: 58.99, H: 9.35, N: 22.93; Found: C: 59.21, H: 9.26, N: 22.59.

후처리

  1. filtrationAt the end of this period, the mixture is filtered
  2. additionof pyridine is added to the filtrate
  3. temperatureThis mixture is heated in an oil bath for one and one-half hours
  4. customthe temperature of the bath below 70°
  5. customThe solid is recrystallized from methanol

출처 및 근거

ORD 기록
ord-23879c3033134182b765916ff9ed125b
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156738

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