참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Biphenyl | HCID 7095 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 3-Methylpentanoyl chloride | HCID 12648279 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Nitrobenzene | HCID 7416 | — |
| 생성물 | (+)-4-(3'-Methylpentanoyl)biphenyl | HCID 21322796 | — |
반응 단계
To commercially available biphenyl (0.08 mole) and anhydrous aluminium trichloride (0.1 mole) dissolved in dry nitrobenzene (90ml), (+)-3-methylpentanoylchloride (0.1mole) the preparation of which is known and described in United Kingdom Patent Application No. 36211/75), is added in drops, the temperature being maintained at about -7° C. during the addition. The mixture is then stirred for about 18 hr. with cooling in an ice bath. It is then poured onto a mixture of ice, water and concentrated hydrochloric acid and stirred for 0.5 hr., and the nitrobenzene layer is separated. The nitrobenzene is removed by steam distillation and the residue is crystallised from a small volume of ethanol to constant melting point.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04149413 |
|---|
| 출처 데이터셋 | uspto-grants-1979_04 |
|---|
| ORD ID | ord-d8bd9553888746338d44dceea6760389 |
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| 출처 메모 | uspto-grants-1979_04 |
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