Methanol → 2-Methoxypyrrolidine-1-carbaldehyde

HRID 26344

반응식

HRID 26344 반응식
[CH:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1)=[O:2].[CH3:8][OH:9]>F[B-](F)(F)F.C[N+](C)(C)C>[CH:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[O:9][CH3:8])=[O:2]

참가 물질

4

반응물 2

HCID 887MethanolHCID 773721-Pyrrolidinecarboxaldehyde2회

생성물 1

HCID 124781712-Methoxypyrrolidine-1-carbaldehyde수율 86.7%

시약·촉매·용매 1

HCID 12621Tetramethylammonium tetrafluoroborate촉매

실험 절차

In the same manner as indicated in Example 5 there are electrolyzed 17.7 g of N-formylpyrrolidine and 57.2 g of methanol in the presence of 0.29 g of tetramethylammonium tetrafluoroborate as conducting salt. In this case, however, the current is switched off after the throughput of already 2.0 Faraday per mol of N-formylpyrrolidine. The calculated mean cell voltage is 28.8 volts. Work-up of the electrolysis solution gives 20.0 g of 1-formyl-2-methoxypyrrolidine (boiling point 39°-40° C./0.1 mbar; nD25 =1.4700), which corresponds to a product yield of 86.6% and a current efficiency of 86.6%.

출처 및 근거

ORD 기록
ord-22e5d01d694a4a47b6ade35b2b0b7bd8
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04149941

연결된 노트

불러오는 중…