Methanol → 1-Benzoyl-2-methyl-6-methoxypiperidine

HRID 26351

반응식

HRID 26351 반응식
[C:1]([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][OH:17]>F[B-](F)(F)F.C[N+](C)(C)C>[C:1]([N:9]1[CH:14]([O:17][CH3:16])[CH2:13][CH2:12][CH2:11][CH:10]1[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 275047N-Benzoyl-2-methylpiperidine2회

생성물 1

HCID 213228541-Benzoyl-2-methyl-6-methoxypiperidine수율 77.6%

시약·촉매·용매 1

HCID 12621Tetramethylammonium tetrafluoroborate촉매

실험 절차

In the same manner as in Example 5, there are electrolyzed 43.8 g of 1-benzoyl-2-methylpiperidine and 60.2 g of methanol in the presence of 0.3 g of tetramethylammonium tetrafluoroborate as conducting salt. After throughput of 2.5 Faraday per mol of 1-benzoyl-2-methylpiperidine the current is switched off. After work-up of the electrolysis solution, 39.0 g of 1-benzoyl-2-methyl-6-methoxypiperidine (boiling point 78°-81° C./0.1 mm Hg; nD25 =1.5340) are obtained which corresponds to a product yield of 77.5% and a current efficiency of 62.0%.

출처 및 근거

ORD 기록
ord-bfde8daec3d34f83be4c725b8a450688
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04149941

연결된 노트

불러오는 중…