Triethylamine → 4-Ethyl-3-o-chlorobenzoyl-4-oxazolin-2-one

HRID 26356

반응식

HRID 26356 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:11]([C:13]1[NH:14][C:15](=[O:18])[O:16][CH:17]=1)[CH3:12].C(N(CC)CC)C>C1C=CC=CC=1>[CH2:11]([C:13]1[N:14]([C:4](=[O:5])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[Cl:1])[C:15](=[O:18])[O:16][CH:17]=1)[CH3:12]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 691102-Chlorobenzoyl chlorideHCID 213229534-Ethyloxazol-2(3H)-one

생성물 1

HCID 213229554-Ethyl-3-o-chlorobenzoyl-4-oxazolin-2-one

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

A solution of o-chlorobenzoyl chloride (1.93 g.) and 4-ethyl-4-oxazolin-2-one (1.13 g.) in 30 ml. of benzene is cooled to 10° C. and reacted with 1.21 g. of triethylamine dissolved in 5 ml. of benzene. The reaction mixture is stirred at room temperature for 1 hour. The excess triethylamine and benzene is removed under reduced pressure to leave a light yellow oil (2.4 g.) which is triturated with ethanol whereupon a crystalline solid separates. The solid is removed and washed with a small amount of cold ethanol and dried. Yield 0.3 g.; m.p. 110°-112° C.

후처리

  1. customreacted with 1.21 g
  2. customThe excess triethylamine and benzene is removed under reduced pressure
  3. customto leave a light yellow oil (2.4 g.) which
  4. customis triturated with ethanol whereupon a crystalline solid separates
  5. customThe solid is removed
  6. washwashed with a small amount of cold ethanol
  7. customdried

출처 및 근거

ORD 기록
ord-b8b94529bf3a4d078af2c164c5aa785e
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150030

연결된 노트

불러오는 중…