3-(4-Methoxyphenyl)-2-methylpropanoic acid → 6-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

HRID 263614

반응식

HRID 263614 반응식
[CH3:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=O>O>[CH3:14][O:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH:2]([CH3:1])[C:3]2=[O:5])=[CH:8][CH:9]=1

참가 물질

3

반응물 1

HCID 105358043-(4-Methoxyphenyl)-2-methylpropanoic acid

생성물 1

HCID 2311786-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

α-Methyl-β-(ρ-methoxyphenyl)propionic acid (15 g.) is added to polyphosphoric acid (170 g.) at 50° C. and the mixture is heated at 83°-90° for two hours. The syrup is poured into iced water, stirred for one-half hour, and then extracted with ether three times. The ether solution is washed with water twice, and with 5% NaHCO3 five times until all the acidic material has been removed. The remaining neutral solution is washed with water and dried over sodium sulfate. Evaporation of the solution gives the indanone as a pale yellow oil.

후처리

  1. temperaturethe mixture is heated at 83°-90° for two hours
  2. extractionextracted with ether three times
  3. washThe ether solution is washed with water twice
  4. customwith 5% NaHCO3 five times until all the acidic material has been removed
  5. washThe remaining neutral solution is washed with water
  6. dry with materialdried over sodium sulfate
  7. customEvaporation of the solution

출처 및 근거

ORD 기록
ord-9b0f8e4202e347eaae7a999e1675d815
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05643959

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