CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
반응식
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1참가 물질
4
실험 절차
To ρ-fluoro-α-methylcinnamic acid (177.9 g., 0.987 mole) in 3.6 l. ethanol is added 11.0 g. of 5% Pd/C and the mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i. Uptake is 31/32 lbs. (97% of theoretical). After filtering the catalyst, the filtrate is concentrated in vacuo to give the product ρ-fluoro-α-methylhydrocinnamic acid used without weighing in next step.
후처리
- customis reduced at room temperature under a hydrogen
- filtrationAfter filtering the catalyst
- concentrationthe filtrate is concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-d11b9a6d66034ab5bd512ecc437e9c4c
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05643959
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