Phosgene → (3R)-oxolan-3-yl carbonochloridate

참여 물질

반응 단계

12.5 ml (24.15 mmol) of a 20% solution of phosgene in toluene are cooled in an ice-bath, a solution of 1.06 g (12.03 mmol) of (R)-(+)-3-hydroxytetrahydrofuran (JPS CHIMIE, Bevaix, Switzerland) in a small amount of toluene is then added dropwise and, after the mixture has been stirred at RT for 2 h, the excess phosgene is expelled with argon. After concentration by evaporation in a rotary evaporator under reduced pressure, the crude title compound is further processed without being further purified.

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