HCID 19035263, 화합물 → 4-Amino-2-(2'-hydroxyethyl)amino-5-methoxytoluene

HRID 263820노트

반응식

HRID 263820 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([O:14][CH3:15])=[CH:7][C:6]=1[CH3:16]>C(O)C.[Pd]>[NH2:11][C:9]1[C:8]([O:14][CH3:15])=[CH:7][C:6]([CH3:16])=[C:5]([NH:4][CH2:3][CH2:2][OH:1])[CH:10]=1

참가 물질

4

반응물 1

HCID 19035263HCID 19035263, 화합물

생성물 1

HCID 190352724-Amino-2-(2'-hydroxyethyl)amino-5-methoxytoluene

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

3 g (15 mmol) of 2-(2'-hydroxyethyl)amino-4-nitro-5-methoxytoluene were hydrogenated using a catalytic amount of Palladium/Carbon (5% Pd) in 100 ml absolute ethanol. After filtration of the catalyst the solvent was completely distilled away and the green crystals were recrystallized from methanol. 2.2 g (83% of the theoretical yield) of the 4-amino-2-(2'-hydroxyethyl)amino-5-methoxytoluene were obtained and melted at 148° C.

후처리

  1. filtrationAfter filtration of the catalyst the solvent
  2. distillationwas completely distilled away
  3. customthe green crystals were recrystallized from methanol

출처 및 근거

ORD 기록
ord-e010a57c823a430cbd7a08a46eb10fc2
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05645610

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