Nitric Acid → 4-Chloro-2-methyl-5-nitroaniline

HRID 263822노트

반응식

HRID 263822 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[N+:10]([O-])([OH:12])=[O:11]>S(=O)(=O)(O)O>[NH2:1][C:2]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 72514-Chloro-2-toluidine

생성물 1

HCID 2929654-Chloro-2-methyl-5-nitroaniline

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

7 g (20 mmol) of 2-amino-5-chlorotoluene were dissolved in 10 ml of sulfuric acid at 10° C. to form a reactant solution. 2.05 ml fuming nitric acid were dissolved in 10 ml concentrated sulfuric acid and the resultant acidic solution was added slowly dropwise to the reactant solution. The reactant solution was then stirred for 3 to 4 hours at room temperature and subsequently added to ice. The yellow product crystals were filtered with suction and recrystallized from methanol. 6.4 g (70% of the theoretical yield) of 2-amino-5-chloro-4-nitrotoluene, which melted at 115° C., were obtained.

후처리

  1. customto form a reactant solution
  2. additionthe resultant acidic solution was added slowly dropwise to the reactant solution
  3. additionsubsequently added to ice
  4. filtrationThe yellow product crystals were filtered with suction
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-9b5a8c1124274c03b660e1b2f36ca95e
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05645610

반응 노트

불러오는 중…