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Methanol → 4-(2,4-Dioxo-8-methyl-1,3,8-triazaspiro[4.5]-decan-3-yl)-2-(trifluoromethyl)-benzonitrile

HRID 264021
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HRID 264021 반응식
N=[C:2]1[C:6]2([CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2)[NH:5][C:4](=[O:13])[N:3]1[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.C[OH:27].[OH-].[NH4+].[Cl-].[Na+]>C(OCC)(=O)C>[O:13]=[C:4]1[N:3]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=2)[C:2](=[O:27])[C:6]2([CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2)[NH:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 887MethanolHCID 5234Sodium ChlorideHCID 14923Ammonium HydroxideHCID 21846478HCID 21846478, 화합물

생성물 1

HCID 218464874-(2,4-Dioxo-8-methyl-1,3,8-triazaspiro[4.5]-decan-3-yl)-2-(trifluoromethyl)-benzonitrile

시약·촉매·용매 1

HCID 8857Ethyl Acetate
용매

실험 절차

Using the procedure of Example 2, 3 g of the product of Example 22, 70 ml of methanol and 17 ml of 2N hydrochloric were reacted and the solution was refluxed for 90 minutes. It was poured into 200 ml of ammonium hydroxide +100 g of ice saturated with sodium chloride and extraction was carried out 4 times with ethyl acetate. The extracts were washed with salt water, dried and purified on silica with methylene chloride-methanol: 9-1 as eluant. After crystallization from methylene chloride-isopropyl ether, 2.12 g of the expected product (white crystals) melting at 188°-189° C were obtained.

후처리

  1. customhydrochloric were reacted
  2. temperaturethe solution was refluxed for 90 minutes
  3. washThe extracts were washed with salt water
  4. customdried
  5. custompurified on silica with methylene chloride-methanol
  6. customAfter crystallization from methylene chloride-isopropyl ether

출처 및 근거

ORD 기록
ord-d44bbc50282a497da1673d545a076bb2
출처 데이터셋
uspto-grants-1997_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05646172

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