참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2,4-Diamino-6-chloropyrimidine | HCID 67432 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178507684 | HCID 178507684 | — |
반응 단계
75 G. of 2,4-diamino-6-chloropyrimidine are dissolved at 35° C. in 1500 ml. of ethanol. The solution is cooled to -10° C. and a solution of 100 g. of 3-chloroperbenzoic acid in 500 ml. of ethanol is slowly added dropwise within 1 hour. The suspension is subsequently stirred at -10° C. for 7 hours and left to stand at 5° C. overnight. The suspension is neutralized with 24 g. of sodium hydroxide in 100 ml. of water. The solid material is filtered off and recrystallized from ethanol, there being obtained pure 2,4-diamino-6-chloropyrimidine-3-oxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04150131 |
|---|
| 출처 데이터셋 | uspto-grants-1979_04 |
|---|
| ORD ID | ord-1994be71994a4b1b94039e3c46ef7df0 |
|---|
| 출처 메모 | uspto-grants-1979_04 |
|---|
