Ethyl 2-bromoisovalerate → ethyl (+/-)-5-dodecyl-alpha-(1-methylethyl)-2H-tetrazole-2-acetate

HRID 264086

반응식

HRID 264086 반응식
[CH2:1]([C:13]1[NH:17][N:16]=[N:15][N:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(C1NN=NN=1)CCCCCCCCC.[CH2:33]([O:35][C:36](=[O:42])[CH:37](Br)[CH:38]([CH3:40])[CH3:39])[CH3:34].BrC1C=CC=CC=1CC(OCC)=O>>[CH2:1]([C:13]1[N:14]=[N:15][N:16]([CH:37]([CH:38]([CH3:40])[CH3:39])[C:36]([O:35][CH2:33][CH3:34])=[O:42])[N:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 4

HCID 79068Ethyl 2-bromoisovalerateHCID 2780092Ethyl 2-(2-bromophenyl)acetateHCID 178442802HCID 178442802, 화합물HCID 178442834HCID 178442834, 화합물

생성물 1

HCID 53709467ethyl (+/-)-5-dodecyl-alpha-(1-methylethyl)-2H-tetrazole-2-acetate

실험 절차

When in the general procedure of Example 71 an appropriate amount of 5-dodecyl-1H-tetrazole was substituted for 5-decyl-1H-tetrazole and an appropriate amount of ethyl-2-bromo-3-methylbutyrate was substituted for ethyl 2-bromophenylacetate, the title compound was obtained. 1H NMR (CDCl3): δ5.26-5.23 (d, 1H); 4.29-4.19 (q, 2H); 2.94-2.77 (m, 3H); 1.82-1.70 (m, 2H); 1.31-1.20 (m, 21H); 1.08-1.05 (d, 3H); 0.97-0.95 (d, 3H) and 0.90-0.85 (t, 3H) ppm.

출처 및 근거

ORD 기록
ord-7fe5cc12a8cb4273a632b97357691aaf
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646170

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