Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
alpha-Angelica lactone → 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | alpha-Angelica lactone | HCID 11559 | — |
| 반응물 | 5-(3-methoxyphenyl)-3,4-dihydro-2H-pyrrole | HCID 12009051 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone | HCID 20332934 | — |
반응 단계
The starting material is prepared as follows: The solution of 70 g of 2-(3-methoxyphenyl)-1-pyrroline [J. Org. Chem. 23, 1278, 1281 (1958)] and 43.2 g of α-angelicalactone in 600 ml of toluene is refluxed overnight. A second portion of 43.2 g of α-angelicalactone is added, the mixture is again refluxed overnight, cooled and evaporated. The residue is crystallized from 50 ml of ethyl acetate, to yield the 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone, melting at 140°-142°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04150129 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-811a6d3800664a58b1f7f400a25bf363 |
| 출처 메모 | uspto-grants-1979_04 |