Dichloromethane → 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride

HRID 264280노트

반응식

HRID 264280 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[C@H:13]([CH:21]([CH3:23])[CH3:22])[C:14]([O:16]C(C)(C)C)=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1.C(Cl)[Cl:32]>>[ClH:32].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[C@H:13]([CH:21]([CH3:23])[CH3:22])[C:14]([OH:16])=[O:15])(=[O:10])=[O:11])=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 6344DichloromethaneHCID 11797104t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoate

생성물 1

HCID 700617032(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride

반응 조건

온도
-10 °C

실험 절차

t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoate (5.3 g, 12.2 mmol) is dissolved in methylene chloride (150 mL) and cooled to -10° C. Hydrochloric acid gas is bubbled into the solution for 10 minutes. The reaction mixture is then sealed, warmed to room temperature and stirred for 4 hours. The solvent is then evaporated to provide 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride.

후처리

  1. customHydrochloric acid gas is bubbled into the solution for 10 minutes
  2. customThe reaction mixture is then sealed
  3. temperaturewarmed to room temperature
  4. customThe solvent is then evaporated

출처 및 근거

ORD 기록
ord-a3aff89067704164b900ff25c9c5c473
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646167

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