Water → (RS)-2-(2-buten-1-yl)-6-methoxy-3,3-dimethyl-1-indanone

HRID 264365

반응식

HRID 264365 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH3:14])([CH3:13])[CH2:8][C:9]2=[O:12])=[CH:5][CH:4]=1.[CH3:15][CH:16](O)[CH:17]=[CH2:18].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>COC(OC)(C)C>[CH2:15]([CH:8]1[C:7]([CH3:14])([CH3:13])[C:6]2[C:10](=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:9]1=[O:12])[CH:16]=[CH:17][CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 117163-Buten-2-olHCID 167432676-Methoxy-3,3-dimethyl-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 54078051(RS)-2-(2-buten-1-yl)-6-methoxy-3,3-dimethyl-1-indanone수율 38%

시약·촉매·용매 1

HCID 64952,2-Dimethoxypropane용매

실험 절차

A solution of 12.1 g of 6-methoxy-3.3-dimethyl-1-indanone, 11.1 ml of 3-buten-2-ol and 110 mg of p-toluenesulfonic acid in 110 ml of 2,2-dimethoxy-propane was boiled under reflux for 67 hours on a water separator filled with molecular sieve (0.4 nm, 2 mm pearl shaped). The reaction mixture was subsequently concentrated in a vacuum and purified by column chromatography on silica gel (hexane/diethyl ether 4:1). In addition to 4.64 g of educt, there were obtained 5.86 g (38%) of (RS)-2-(2-buten-1-yl)-6-methoxy-3,3-dimethyl-1-indanone as a yellow oil.

후처리

  1. additionseparator filled with molecular sieve (0.4 nm, 2 mm pearl shaped)
  2. concentrationThe reaction mixture was subsequently concentrated in a vacuum
  3. custompurified by column chromatography on silica gel (hexane/diethyl ether 4:1)
  4. additionIn addition to 4.64 g of educt

출처 및 근거

ORD 기록
ord-d91c2662313c4fd39d9017d7107a553b
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646173

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