Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → (2R*,4S*)-2-benzyl-1-(2-naphthylacetyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Naphthaleneacetic acid | HCID 11393 | — |
| 반응물 | 1-Chloro-N,N-2-trimethylpropenylamine | HCID 640792 | — |
| 반응물 | (2R*,4S*)-2-Benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57202094 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | (2R*,4S*)-2-benzyl-1-(2-naphthylacetyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57233831 | — |
반응 단계
105 mg (0.561 mmol) of 2-naphtylacetic acid are reacted in analogy to Example 6 first 92 μl (0.655 mmol) of 1-chloro-N,N,2-trimethyl-1-propen-1-amine and subsequently with 200 mg (0.468 mmol) of (2R*,4S*)-2-benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine and 130 μl (0.936 mmol) of triethylamine to give the product TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.56, FD-MS: M+ =595.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05646144 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-af7fb0b602b241f5bb6bfdd2b94efd73 |
| 출처 메모 | uspto-grants-1997_07 |