Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dichlorobenzoic acid → (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dichlorobenzoic acid | HCID 5811 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | (2R*,4S*)-2-Benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 22863105 | — |
| 생성물 | (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57094766 | 60.4% |
반응 단계
189 mg (0.992 mmol) of 3,5-dichlorobenzoic acid are reacted in analogy to Example 2a first with 0.108 ml (1.49 mmol) of thionyl chloride and subsequently with 155 mg (0.397 mmol) of (2R*,4S*)-2-benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine and 166 μl (1.19 mmol) of triethylamine to give the title compound (135 mg, 60%). TLC:methylene chloride/methanol/cone. ammonia (1000:50:1) Rf =0.70, FD-MS:M+ =562, 564.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05646144 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-34c39a1dc1754392837773338f18b7bc |
| 출처 메모 | uspto-grants-1997_07 |