Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric acid magnesium salt (1:1) → (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(5-methoxyindol-3-yl-methyl)-4-piperidinamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | 5-Methoxyindole-3-carbaldehyde | HCID 82758 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine | HCID 53839030 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(5-methoxyindol-3-yl-methyl)-4-piperidinamine | HCID 57096920 | — |
반응 단계
200 mg (0.551 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 2g with 116 mg (0.661 mmol) of 5-methoxyindole-3-carboxaldehyde and 90 mg of magnesium sulfate in 2 ml of toluene and subsequently reduced with 22 mg (0.584 mmol) of sodium borohydride in 2 ml of methanol. The title compound ##STR95## is obtained (98 mg, 34%) as white foam. TLC:methylene chloride/methanol/conc. ammonia (1000:50:1) Rf =0.42, FD-MS:M+ =521, 523. IR:3460, 1630 cm-1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05646144 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-5839ecc9d3a245e79728dd922682aff3 |
| 출처 메모 | uspto-grants-1997_07 |