Ammonia → 2-Aminoadenosine

HRID 264715

반응식

HRID 264715 반응식
[NH3:1].O.[C@@H:3]1([N:12]2[C:22]3[N:21]=[C:19]([NH2:20])[NH:18][C:16](=O)[C:15]=3[N:14]=[CH:13]2)[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]1[OH:5].Cl[Si](C)(C)C>O>[NH2:20][C:19]1[N:21]=[C:22]2[C:15]([N:14]=[CH:13][N:12]2[C@@H:3]2[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]2[OH:5])=[C:16]([NH2:1])[N:18]=1

참가 물질

5

반응물 3

HCID 222Ammonia2회HCID 6397ChlorotrimethylsilaneHCID 135705230Guanosine Hydrate

생성물 1

HCID 722002-Aminoadenosine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

This variation of the procedures of Robins, et al. supra, eliminated the need to utilize liquid ammonia in the reaction mixture since the ammonia molecule is generated in situ from the silazane reagent and the water of hydration of the guanosine hydrate starting material. Further, the use of chlorotrimethylsilane was not necessary nor was it necessary to conduct the reaction under anhydrous conditions, do a preliminary evaporation, or open and re-seal the Parr bomb under a dry nitrogen atmosphere.

후처리

  1. customthe reaction under anhydrous conditions
  2. customa preliminary evaporation
  3. customopen and re-seal the Parr bomb under a dry nitrogen atmosphere

출처 및 근거

ORD 기록
ord-494fc1639bc14d2596e0d0c070bd9931
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646265

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