Dihydroxyacetone → 2-(5-Bromo-2-methoxyphenyl)-4-hydroxymethylimidazole

HRID 264750

반응식

HRID 264750 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[NH:8].[OH:13][CH2:14][C:15]([CH2:17]O)=O.[Cl-].[NH4+].[OH-].[NH4+]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([C:7]2[NH:9][C:15]([CH2:14][OH:13])=[CH:17][N:8]=2)[CH:10]=1

참가 물질

6

반응물 4

HCID 670DihydroxyacetoneHCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 103537555-Bromo-2-methoxy-benzamidine

생성물 1

HCID 103340042-(5-Bromo-2-methoxyphenyl)-4-hydroxymethylimidazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
90 °C

실험 절차

A mixture of 5-Bromo-2-methoxy-benzamidine (1.5 g), 1,3-dihyroxy-acetone dimer (1.0 g), ammonium chloride (1.3 g), tetrahydrofuran (3 mL) and concentrated aqueous ammonium hydroxide (10 mL) was heated at 90° C. for 3 h. The reaction mixture was chilled on ice and the precipitated product was collected and recrystallized from methanol to afford 2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole as a yellow solid.

후처리

  1. temperatureThe reaction mixture was chilled on ice
  2. customthe precipitated product was collected
  3. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-17e3e23b2fc94c69b3f5f7704671c0c4
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646280

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