Ammonium Chloride → 2-(p-Tolyl)imidazole-5-methanol

HRID 264761

반응식

HRID 264761 반응식
Cl.[CH3:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][CH:4]=1.[OH:12][CH:13](O)[C:14](=O)[CH3:15].[Cl-].[NH4+]>[OH-].[NH4+]>[CH3:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[NH:8][C:14]([CH2:13][OH:12])=[CH:15][N:9]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 1227534-Methylbenzene-1-carboximidamide hydrochlorideHCID 131809821,1-Dihydroxypropan-2-one

생성물 1

HCID 130112422-(p-Tolyl)imidazole-5-methanol

시약·촉매·용매 1

HCID 14923Ammonium Hydroxide용매

반응 조건

온도
90 °C

실험 절차

A solution of 4 g 4-methylbenzamidine hydrochloride in 60 mL ammonium hydroxide was treated with 4.0 g with dihydroxyacetone and 4.8 g ammonium chloride. The reaction mixture was heated to 90° C. for 4 hours in a sealed tube. On cooling to room temperature a the solid formed was collected by filtration to yield 3.0 g 2-(4-methylphenyl)-5-hydroxymethyl-imidazole which was converted according to the procedure described in Example VII to yield 2-(4-methylphenyl-4(5)-[(4-(2-pyrimidinyl)-piperazin-1-yl)-methyl]-imidazole (Compound 133), m.p. 178°-180° C.

후처리

  1. temperatureOn cooling to room temperature a the solid
  2. customformed
  3. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-3e9433fd1309492e9eef1bc0b7c75437
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646281

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