참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acrylate | HCID 8821 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | 3-Benzyloxy-6-hydroxymethyl-2-iodopyridine | HCID 19692712 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate | HCID 86751041 | 62% |
반응 단계
To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05646286 |
|---|
| 출처 데이터셋 | uspto-grants-1997_07 |
|---|
| ORD ID | ord-3b9686b7cdd04c39bcff3ecc3658d90a |
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| 출처 메모 | uspto-grants-1997_07 |
|---|
