참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
| 반응물 | 2-iso Butyramido-4-methyloxazole | HCID 23348562 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole | HCID 21323668 | — |
반응 단계
2-iso Butyramido-4-methyloxazole (11.1 g., 0.066 mol) prepared in a manner similar to that described in Example 20, was dissolved in dry dimethylformamide. Solid potassium carbonate (10.47 g., 0.076 mol) and 3-chlorobenzyl bromide (15.6 g., 0.076 mol) were added and the stirred mixture was heated at 70° C. for 2 hours, cooled and poured into cold water. The solution was extracted with ether and the extract was dried over magnesium sulphate and evaporated. The residue was distilled to give the product, 12.3 g., b.p. 115-120° C./0.08 mm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04150143 |
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| 출처 데이터셋 | uspto-grants-1979_04 |
|---|
| ORD ID | ord-67daa2cca30b41ff8b2d549f760e35e1 |
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| 출처 메모 | uspto-grants-1979_04 |
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