Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Indanone → 2,3-Dihydro-N-benzyl-1H-inden-1-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Indanone | HCID 6735 | — |
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 2,3-Dihydro-N-benzyl-1H-inden-1-amine | HCID 10130724 | — |
반응 단계
The amino acid was synthesized as described by Miyake, et al., Takeda Kenkyushoho 44: 171-185 (1985). [Chem. Abstr. 106: 156830 (1987)]. N-(1-indanyl)-benzylamine was prepared by reductive amination of 1-indanone with benzylamine, and alkylation of the amine by ethyl bromoacetate. The benzyl group was cleaved by hydrogenolysis over palladium. Saponification of the ethyl ester gave the amino acid, which was converted to the Boc derivative by the standard procedure described in Example III.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648336 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-7f2f1b591a2445f18913943b894b5a90 |
| 출처 메모 | uspto-grants-1997_07 |