1-Indanone → 2,3-Dihydro-N-benzyl-1H-inden-1-amine

HRID 265228

반응식

HRID 265228 반응식
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.BrCC(OCC)=O>[Pd]>[CH:1]1([NH:18][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 67351-IndanoneHCID 7504BenzylamineHCID 7748Ethyl bromoacetate

생성물 1

HCID 101307242,3-Dihydro-N-benzyl-1H-inden-1-amine

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The amino acid was synthesized as described by Miyake, et al., Takeda Kenkyushoho 44: 171-185 (1985). [Chem. Abstr. 106: 156830 (1987)]. N-(1-indanyl)-benzylamine was prepared by reductive amination of 1-indanone with benzylamine, and alkylation of the amine by ethyl bromoacetate. The benzyl group was cleaved by hydrogenolysis over palladium. Saponification of the ethyl ester gave the amino acid, which was converted to the Boc derivative by the standard procedure described in Example III.

후처리

  1. customThe amino acid was synthesized

출처 및 근거

ORD 기록
ord-7f2f1b591a2445f18913943b894b5a90
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648336

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