3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazapine → 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

반응식

CS([C:5]1[N:14]2[C:8]([CH2:9][C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[CH:12]=[CH:13]2)=[N:7][N:6]=1)(=O)=O.[O-:19][CH2:20][CH3:21].[Na+].C(O)C.C[O-].[Na+].CO>>[CH2:20]([O:19][C:5]1[N:14]2[C:8]([CH2:9][C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[CH:12]=[CH:13]2)=[N:7][N:6]=1)[CH3:21]

참가 물질

반응물 3

HCID 213235253-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazapine

HCID 23694274Sodium methanolate methanol

HCID 23706232Ethanol sodium ethoxide

생성물 1

HCID 213233563-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

실험 절차

By a procedure similar to that described in Example 34, 3-methylsulfonyl-11H-s-triazolo[3,4-b][3] benzazepine was reacted with sodium ethoxide/ethanol, in lieu of sodium methoxide/methanol, to obtain 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine as crystals. Recrystallization from acetone yielded colorless needles, melting point: 143°-144° C.

출처 및 근거

ORD 기록: ord-19fc2532158f4abeb00ecd2283c89a51
출처 데이터셋: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04150139

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