HCID 22218187, 화합물 → 3-methanesulfonyl-2-methylpropanoic acid

HRID 265267노트

반응식

HRID 265267 반응식
[CH3:1][S:2]([CH2:5][C:6](=[CH2:10])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[CH3:10][CH:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 22218187HCID 22218187, 화합물

생성물 1

HCID 221423443-methanesulfonyl-2-methylpropanoic acid수율 96.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-(methylsulfonylmethyl) acrylic acid (700 mg, 4.26 mmol) in 20 mL of methanol was charged into a Fisher-Porter bottle along with 10% palladium on carbon catalyst under a nitrogen atmosphere. The reaction vessel was sealed and flushed five times with nitrogen and then five times with hydrogen. The pressure was maintained at 50 psig for 16 hours and then the hydrogen was replaced with nitrogen and the solution filtered through a pad of celite to remove the catalyst and the filtrate concentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid; formula: ##STR79##

후처리

  1. customThe reaction vessel was sealed
  2. customflushed five times with nitrogen
  3. temperatureThe pressure was maintained at 50 psig for 16 hours
  4. filtrationthe solution filtered through a pad of celite
  5. customto remove the catalyst
  6. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-c9014f142df34cdea9215baf05f8a84a
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648364

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