Sodium Bicarbonate → 4-Hydroxy-7-[2-[[3-[[2-(2-phenylethoxy)ethyl]sulfonyl]propyl]amino]ethyl]-2(3H)-benzothiazolone
반응식
Cl.[OH:2][C:3]1[C:8]2[NH:9][C:10](=[O:12])[S:11][C:7]=2[C:6]([CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][S:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:21])=[O:20])=[CH:5][CH:4]=1.C(=O)([O-])O.[Na+]>>[OH:2][C:3]1[C:8]2[NH:9][C:10](=[O:12])[S:11][C:7]=2[C:6]([CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][S:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)(=[O:21])=[O:20])=[CH:5][CH:4]=1참가 물질
3
실험 절차
An aqueous solution (500 ml) of the title compound from Example 20 (4.9 g) was mixed with an excess of aqueous sodium hydrogen carbonate. The free base was extracted with chloroform and the combined extracts were washed with water and dried (MgSO4), filtered and the chloroform removed under reduced pressure to yield the subtitled compound as an off-white solid (4.22 g, 91%).
후처리
- extractionThe free base was extracted with chloroform
- washthe combined extracts were washed with water