2-Chloro-1-(2,4-difluorophenyl)ethanone → 1-(2,4-Difluorophenyl)-1-(6-cyanobenzothiazol-2-YL)-2-chloroethanol

HRID 265323

반응식

HRID 265323 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].[C:13]([C:15]1[CH:23]=[CH:22][C:18]2[N:19]=[CH:20][S:21][C:17]=2[CH:16]=1)#[N:14].C([Li])CCC>>[F:12][C:6]1[CH:7]=[C:8]([F:11])[CH:9]=[CH:10][C:5]=1[C:3]([C:20]1[S:21][C:17]2[CH:16]=[C:15]([C:13]#[N:14])[CH:23]=[CH:22][C:18]=2[N:19]=1)([OH:4])[CH2:2][Cl:1]

참가 물질

4

반응물 3

HCID 5880832-Chloro-1-(2,4-difluorophenyl)ethanoneHCID 10607144Benzothiazole-6-carbonitrileHCID 178418339Butyllithium

생성물 1

HCID 105940491-(2,4-Difluorophenyl)-1-(6-cyanobenzothiazol-2-YL)-2-chloroethanol

실험 절차

2-Chloro-2',4'-difluoroacetophenone is added to 6-cyanobenzothiazole in the presence of n-butyllithium to form 1-(2,4-difluorophenyl)-1-(6-cyanobenzothiazol-2-yl)-2-chloroethanol.

출처 및 근거

ORD 기록
ord-d1d9b4e3d1c0443082a44aa6febfb0e1
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648372

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