2,4,5-Triphenylimidazole → HCID 86751077, 화합물

HRID 265355

반응식

HRID 265355 반응식
[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrC[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=O.[C:37](=O)([O-])[O-:38].[K+].[K+]>CC(=O)CC>[CH2:35]([O:34][C:32](=[C:37]=[O:38])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][N:11]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:9]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:8]=[C:7]1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:36]

참가 물질

5

반응물 3

HCID 102322,4,5-TriphenylimidazoleHCID 11430Potassium CarbonateHCID 264813Ethyl 8-bromooctanoate

생성물 1

HCID 86751077HCID 86751077, 화합물수율 48.5%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 2,4,5-triphenylimidazole (11 g), ethyl 8-bromooctanoate (18.64 g), anhydrous potassium carbonate (51.3 g) and dry butanone (350 ml) was heated at reflux for 26 h. The cooled reaction mixture was filtered to remove inorganics and the filtrate was evaporated to dryness in vacuo. The residue was stirred in hexane and unreacted 2,4,5-triphenylimidazole was collected by filtration (3.1 g). The filtrate was cooled and a white precipitate was collected. Recrystallisation from hexane gave 1-(7-ethoxy-carbonyl-heptyl)-2,4,5-triphenylimidazole (8.37 g, 48.4%) as a white solid, m.p. 65°-7°.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 26 h
  3. customThe cooled reaction mixture
  4. filtrationwas filtered
  5. customto remove inorganics
  6. customthe filtrate was evaporated to dryness in vacuo
  7. filtrationunreacted 2,4,5-triphenylimidazole was collected by filtration (3.1 g)
  8. temperatureThe filtrate was cooled
  9. customa white precipitate was collected
  10. customRecrystallisation from hexane

출처 및 근거

ORD 기록
ord-de315edf787b4354befe83bbfa06f099
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648373

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