Potassium Carbonate → 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone

HRID 26545노트

반응식

HRID 26545 반응식
Cl.[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 51199Nafimidone monohydrochloride

생성물 1

HCID 512002-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

1-(2-Naphthoylmethyl)imidazole hydrochloride (1.0 g.) suspended in 50 ml. of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-(2-naphthoylmethyl)imidazole.

후처리

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-db5c8d01e01c4b6882b725e1358bba66
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150153

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