HCID 53764590, 화합물 → HCID 54677766, 화합물

반응식

[O:1]=[C:2]([NH:8][C:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=1[C:15]([O:17]CC)=O)[CH2:3][C:4]([O:6][CH3:7])=[O:5].O=C(NC1CCCCC=1C(OC)=O)CC(OC)=O>>[OH:17][C:15]1[C:10]2[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=2[NH:8][C:2](=[O:1])[C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

반응물 2

HCID 53764590HCID 53764590, 화합물

HCID 54067855HCID 54067855, 화합물

생성물 1

HCID 54677766HCID 54677766, 화합물

실험 절차

Using the general method of Example 1 Part D, a mixture of methyl 3-oxo-3-[(2-ethoxycarbonylcyclohexen-1-yl)amino]propanoate and methyl 3-oxo-3-[(2-methoxycarbonylcyclohexen-1-yl)amino]propanoate (43.2 g, 0.16 mole) was cyclized to provide 35.5 g of methyl 1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxoquinoline-3-carboxylate as an off white solid.

출처 및 근거

ORD 기록: ord-1a67bc7565a44d26bee87da9ff95ee0b
출처 데이터셋: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05648516

반응 노트

불러오는 중…