Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylparaben → Methyl 4-[2-(N-BOC-4-Piperidinyl)ethyloxy]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylparaben | HCID 7456 | — |
| 반응물 | Tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate | HCID 9974426 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 4-[2-(N-BOC-4-Piperidinyl)ethyloxy]benzoate | HCID 10832539 | — |
반응 단계
A solution of methyl 4-hydroxybenzoate (Aldrich) (0.4 g, 2.6 mmoles) 9-1 in DMF (10 ml) was treated with 2-(N-Boc-4-piperidinyl)ethyl iodide 1-4 (0.6 g, 1.77 mmoles) and CS2CO3 (1.15 g, 3.5 mmoles) with stirring at room temperature for 48 hours. The reaction mixture was diluted with EtOAc, washed with H2O, saturated NaHCO3, 10% KHSO4, brine dried (MgSO4) and concentrated. The residue was purified by flash chromatography on silica gel eluting with 20% EtOAc/hexanes to give pure 9-2. Rf 0.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648368 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-b79d2a287dc44b13910f9db9d2875f8f |
| 출처 메모 | uspto-grants-1997_07 |