Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Ethyl 3-[4-(N-BOC-hydroxypiperidin-4-yl)phenyl]butyrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Ethyl 3-[4-(N-BOC-4-hydroxypiperidin-4-yl)phenyl]crotonate | HCID 67721045 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | Ethyl 3-[4-(N-BOC-hydroxypiperidin-4-yl)phenyl]butyrate | HCID 19034119 | — |
반응 단계
A mixture of 12-1 (400 mg, 1.0 mmoles), 10% Pd/C (160 mg), and CH3OH (5 mL) was stirred at ambient temperature under a hydrogen atmosphere for 3.0 hours. The reaction mixture was filtered through a celite pad and the filtrate concentrated to give 12-2 as a yellow oil. Rf 0.33 (silica, 30% EtOAc/hexanes).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648368 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-452d160c4ea84adc9e7602413fe534c7 |
| 출처 메모 | uspto-grants-1997_07 |