Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-Benzyl-4-cyano-4-phenylpiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Phenylpiperidine-4-carbonitrile hydrochloride | HCID 3084973 | — |
| 용매 | Oxolane--water (1/1) | HCID 21881883 | — |
| 생성물 | 1-Benzyl-4-cyano-4-phenylpiperidine | HCID 191408 | — |
반응 단계
4-Phenyl-4-cyano-piperidine hydrochloride (10 g, 44.9 mmol), Benzyl bromide (5.4 mL, 45.4 mmol), and potassium carbonate (25.2g, 182.3 mmol) were combined in THF/water (80 mL/20 mL). After 18 hours the reaction mixture was partitioned between water and dichloromethane. The organic layer was separated and extracted with water, dried over MgSO4, filtered and evaporated in vacuo to give a residue. The residue was recrystallized from hexane to give 4-phenyl-4-cyano-1-benzyl-piperidine as a solid: mp=73°-74° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648366 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-3b7793d51c37494998f5810dcc5c41e1 |
| 출처 메모 | uspto-grants-1997_07 |