Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → [2-(4-Chlorobenzothiazolyl)][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(2-Bromoethyl)-4-methoxybenzene | HCID 84427 | — |
| 반응물 | [2-(4-Chlorobenzothiazolyl)](4-piperidinyl)methanone | HCID 53815766 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | [2-(4-Chlorobenzothiazolyl)][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone | HCID 54412977 | — |
반응 단계
Mix [2-(4-chlorobenzothiazolyl)](4-piperidinyl)methanone.CF3CO2H (9.19 mmol), 2-(4-methoxyphenyl)ethyl bromide (2.07 g, 9.64 mmol), potassium carbonate (3.33 g, 24.1 mmol) and dimethylformamide (35 mL) and heat at 90° C. overnight. Cool to room temperature and partition between a 2:1 mixture of ethyl acetate/toluene and water. Separate the aqueous phase and wash the organic phase with water and brine. Dry (MgSO4) and evaporate the solvent in vacuo. Purify by chromatography to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05650416 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-8ac0bccc17544f73a370f0721b0c23b8 |
| 출처 메모 | uspto-grants-1997_07 |