4-Phenylcyclohexylamine → Ethyl 2,6-dimethyl-4-(4-phenylcyclohexylamino)nicotinate

반응식

Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[CH:3]=1.[C:15]1([CH:21]2[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:13][C:6]1[N:5]=[C:4]([CH3:14])[CH:3]=[C:2]([NH:27][CH:24]2[CH2:23][CH2:22][CH:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:26][CH2:25]2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

참가 물질

반응물 2

HCID 298974-Phenylcyclohexylamine

HCID 239536Ethyl 4-chloro-2,6-dimethylnicotinate

생성물 1

HCID 19032606Ethyl 2,6-dimethyl-4-(4-phenylcyclohexylamino)nicotinate

실험 절차

was prepared analogously to Example 8 using ethyl 4-chloro-2,6-dimethylnicotinate and 4-phenylcyclohexylamine. nD23 :1.5389.

출처 및 근거

ORD 기록: ord-3dbf6a35c51745359b624d1a6a336df2
출처 데이터셋: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05650417

반응 노트

불러오는 중…